The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2006
Filed:
Oct. 02, 2002
Jan Susan Rosenbaum, Cincinnati, OH (US);
David R. Jones, Milford, OH (US);
George Brian Whitaker, West Chester, OH (US);
Jan Susan Rosenbaum, Cincinnati, OH (US);
David R. Jones, Milford, OH (US);
George Brian Whitaker, West Chester, OH (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
Peptides that specifically interfere with the ability of VEGFto interact with the NP-1 receptor or with a VEGFR-2/NP-1 co-receptor complex are disclosed. The inventive peptides are useful to control pathological angiogenesis, such as occurs in cancer and other diseases. The peptides are based on a combination of basic residues contained within Exon 6 of human placental growth factor (PIGF), coupled at the carboxyl terminus to either Exon 8 of VEGFor Exon 7 of PIGF. The peptides behave as antagonists of VEGFsignaling through a mechanism that involves competition for VEGFbinding at either the VEGFR-2/NP-1 complex or NP-1, without affecting VEGF signaling through other pathways. This binding is sufficient to attenuate pathological angiogenesis such as occurs in tumor growth.