The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2006
Filed:
Mar. 07, 2002
Rita Vanbever, Brussels, BE;
Robert S. Langer, Newton, MA (US);
David A. Edwards, Boston, MA (US);
Jeffrey Mintzes, Brighton, MA (US);
Jue Wang, Clifton, NJ (US);
Donghao Chen, Lexington, MA (US);
Rita Vanbever, Brussels, BE;
Robert S. Langer, Newton, MA (US);
David A. Edwards, Boston, MA (US);
Jeffrey Mintzes, Brighton, MA (US);
Jue Wang, Clifton, NJ (US);
Donghao Chen, Lexington, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
The Penn State Research Foundation, University Park, PA (US);
Abstract
The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a polycationic complexing agent which is complexed with a therapeutic, prophylactic or diagnostic agent or any combination thereof having a charge capable of complexing with the polycationic complexing agent upon association with the bioactive agent. The particles can further comprise a pharmaceutically acceptable carrier. The amount of polycationic complexing agent present in the particles is an amount sufficient to sustain the release of diagnostic, therapeutic or prophylactic agent from the particles. For example, the amount of complexing agent present can be at about 5% weight/weight (w/w) or more of the total weight of the complexing agent and therapeutic, diagnostic or prophylactic agent. Release of the agent from the administered particles occurs in a sustained fashion.