The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2006
Filed:
Apr. 05, 2001
Ying-fei Wei, San Mateo, CA (US);
Reiner Gentz, Silver Spring, MD (US);
Jian NI, Rockville, MD (US);
Steven M Ruben, Olney, MD (US);
Ying-Fei Wei, San Mateo, CA (US);
Reiner Gentz, Silver Spring, MD (US);
Jian Ni, Rockville, MD (US);
Steven M Ruben, Olney, MD (US);
Human Genome Sciences, Inc., Rockville, MD (US);
Abstract
The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as 'TNFR-5' or 'TR5,' and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.