Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents

Abstract

This invention relates to compounds which have activity as 5-HTagonists and antagonists which may be useful for the treatment of anxiety, depression, cognitive deficits, and prostate cancer, having the formula wherein: X is a moiety selected from the group of: n is selected from the integers 1 through 5; Ris optionally substituted aryl or mono or bicyclic heteroaryl, with a proviso that heteroaryl is not thiadiazole; Ris H or alkyl; Ris H, COR, COOR, and CONRR; Ris H, alkyl, alkenyl, alkynyl, aryl, mono or bicyclic heteroaryl, aralkyl, and mono or bicyclic heteroaralkyl, wherein the aryl or heteroaryl groups are optionally substituted; Rand Rare H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, adamantyl, and noradamantyl or Rand Rtaken together may form a 5–7 membered azacyclic ring, optionally containing an additional heteroatom selected from O, S, or NR; when Ror Rare chosen from cycloalkyl or cycloalkenyl, the cyclic group may optionally be substituted at the 1-position with a C–Calkyl group;or an optical isomer; or a pharmaceutically acceptable salt thereof.