The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2006
Filed:
Jul. 09, 2004
Kevin J. Lee, New York, NY (US);
Richard Axel, New York, NY (US);
Walter Strapps, New York, NY (US);
Gilad Barnea, New York, NY (US);
Kevin J. Lee, New York, NY (US);
Richard Axel, New York, NY (US);
Walter Strapps, New York, NY (US);
Gilad Barnea, New York, NY (US);
Sentigen Biosciences, Inc., New York, NY (US);
The Trustees of Columbia University of the City of New York, New York, NY (US);
Abstract
The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.