The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2006
Filed:
Oct. 01, 2001
Michael R. Bristow, Greenwood Village, CO (US);
Leslie A. Leinwand, Boulder, CO (US);
Wayne Minobe, Golden, CO (US);
Koichi Nakao, Kumamoto, JP;
Koichiro Kinugawa, Denver, CO (US);
Michael R. Bristow, Greenwood Village, CO (US);
Leslie A. Leinwand, Boulder, CO (US);
Wayne Minobe, Golden, CO (US);
Koichi Nakao, Kumamoto, JP;
Koichiro Kinugawa, Denver, CO (US);
The Regents of the University of Colorado, Boulder, CO (US);
Abstract
The present invention provides methods of diagnosing myocardial failure in a human. The methods comprise obtaining a sample of myocardial tissue from a ventricle of the heart. In one embodiment, the expression of α-myosin heavy chain, β-myosin heavy chain, or both, are quantitated and their expression levels compared to that seen normal human ventricular myocardial tissues. In another embodiment, the expression of α1-thyroid hormone receptor, α2-thyroid hormone receptor, a α1-thyroid hormone receptor+β1-thyroid hormone receptor, or combinations thereof, are quantitated, and their expression levels compared to that seen normal human ventricular myocardial tissues. Therapeutic interventions based on altering the expression of the aforementioned genes also are provide.