The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2006
Filed:
Nov. 10, 1998
Joseph G Sodroski, Medford, MA (US);
Richard T. Wyatt, Andover, MA (US);
Peter D. Kwong, New York, NY (US);
Wayne A. Hendrickson, New York, NY (US);
Michael Farzan, Brookline, MA (US);
Joseph G Sodroski, Medford, MA (US);
Richard T. Wyatt, Andover, MA (US);
Peter D. Kwong, New York, NY (US);
Wayne A. Hendrickson, New York, NY (US);
Michael Farzan, Brookline, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
Abstract
A modified polypeptide corresponding to an envelope glycoprotein of a primate lentivirus is described. The polypeptide has been modified from the wild-type structure so that it has cysteine amino acid residues introduced to create disulfide bonds, a cavity is filled with hydrophobic amino acids, a Proresidue is introduced at a defined turn structure of the protein, or the hydrophobicity is increased across the interface between different domains, while retaining the overall 3-dimensional structure of a discontinuous conserved epitope of the wild-type protein. Preferably, the polypeptide has more than one of those characteristics. Preferably, the primate lentivirus is HIV, and the protein is HIV-1 gp120.