The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2006
Filed:
Apr. 08, 2002
Heinz-hermann Bokel, Darmstadt, DE;
Steffen Neuenfeld, Messel, DE;
Ludwig Gantzert, Pfungstadt, DE;
Ralf Knierieme, Gross-Zimmern, DE;
Elke Simon, Gross-Zimmern, DE;
Ralf Devant, Darmstadt, DE;
Udo Helm, Michelstadt, DE;
Helmut Reubold, Bad Koenig, DE;
Heinz-Hermann Bokel, Darmstadt, DE;
Steffen Neuenfeld, Messel, DE;
Ludwig Gantzert, Pfungstadt, DE;
Ralf Knierieme, Gross-Zimmern, DE;
Elke Simon, Gross-Zimmern, DE;
Ralf Devant, Darmstadt, DE;
Udo Helm, Michelstadt, DE;
Helmut Reubold, Bad Koenig, DE;
Merck Patent GmbH, Darmstadt, DE;
Abstract
The present invention relates to a process for the preparation of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, the enantiomers and its salts, characterised in that 5-(4-fluorophenyl)pyridine-3-carbaldehyde is reacted directly with aminomethylchroman or its salts under reducing conditions to give 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, and the latter is, if desired, converted into one of its physiologically acceptable salts by treatment with an acid.