2-(pyrazol-3-yl)carbapenem derivatives

Abstract

A compound of formula (I):whereinRis hydrogen, optionally substituted (C)alkyl or optionally substituted aryl;Ris hydrogen, optionally substituted (C)alkyl or optionally substituted aryl; orRand Rtogether form an optionally substituted 5 or 6 membered heterocyclic ring with or without additional heteroatoms;Ris (C)alkyl which is unsubstituted or substituted by fluoro, a hydroxy group which is optionally protected by a removable hydroxy protecting group, or by an amino group which is optionally protected by a removable amino protecting group;Ris hydrogen or methyl; and—CORis carboxy or a carboxylate anion or the group Ris a removable carboxy protecting group. This invention also relates to processes for its preparation, intermediates and pharmaceutical compositions comprising compounds of formula (I). Compounds of formula (I) which include pharmaceutically acceptable salts or pharmaceutically acceptable in vivo hydrolysable esters thereof have a broad spectrum of anti-bacterial activity and show good stability towards DHP-1.