The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2006
Filed:
Oct. 31, 2001
Susan L. Acton, Lexington, MA (US);
Timothy D. Ocain, Framingham, MA (US);
Alexandra E. Gould, Cambridge, MA (US);
Natalie A. Dales, Arlington, MA (US);
Bing Guan, Brighton, MA (US);
James A. Brown, Framingham, MA (US);
Michael Patane, Andover, MA (US);
Vivek J. Kadambi, Boxboro, MA (US);
Michael Solomon, Medford, MA (US);
Alain Stricker-krongrad, Lexington, MA (US);
Susan L. Acton, Lexington, MA (US);
Timothy D. Ocain, Framingham, MA (US);
Alexandra E. Gould, Cambridge, MA (US);
Natalie A. Dales, Arlington, MA (US);
Bing Guan, Brighton, MA (US);
James A. Brown, Framingham, MA (US);
Michael Patane, Andover, MA (US);
Vivek J. Kadambi, Boxboro, MA (US);
Michael Solomon, Medford, MA (US);
Alain Stricker-Krongrad, Lexington, MA (US);
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include compounds of formula (I):Z-Λ  (I)Wherein Z is a zinc coordinating moiety and Λ is an amino-acid mimicking moiety, and pharmaceutically acceptabale salts thereof. Methods of using the inhibitors and pharmaceutical compositions containing the inhibitors to treat a body weight disorder, to decrease appetite, to increase muscle mass, to decrease body fat, to treat diabetes and to treat a state associated with altered lipid metabolism, are also described.