The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2006
Filed:
Jun. 10, 2002
Revati J. Tatake, Sandy Hook, CT (US);
Richard Schneiderman, Sandy Hook, CT (US);
Randall Wilber Barton, Farmington, CT (US);
Revati J. Tatake, Sandy Hook, CT (US);
Richard Schneiderman, Sandy Hook, CT (US);
Randall Wilber Barton, Farmington, CT (US);
Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefleid, CT (US);
Abstract
Unique multifunctional nucleotide expression cassettes comprising a nucleotide sequence encoding a human protease driven by a glucose-regulatable promoter, a nucleotide sequence encoding human proinsulin having sites at its B-C and C-A junctions altered to permit cleavage by the human protease, and a CMV promoter driving the transcription of the nucleotide sequence encoding the human proinsulin, such cassettes optionally having polyadenylation sequences after each structural gene and the nucleotide sequence encoding human proinsulin optionally carrying an H10D variant, and cells transformed thereby.