The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 09, 2006

Filed:

Apr. 24, 2003
Applicants:

Ian James Collins, Redhill, GB;

Laura Catherine Cooper, Puckeridge, GB;

Timothy Harrison, Great Dunmow, GB;

Linda Elizabeth Keown, Great Dunmow, GB;

Andrew Madin, Sawbridgeworth, GB;

Mark Peter Ridgill, Watton-At-Stone, GB;

Inventors:

Ian James Collins, Redhill, GB;

Laura Catherine Cooper, Puckeridge, GB;

Timothy Harrison, Great Dunmow, GB;

Linda Elizabeth Keown, Great Dunmow, GB;

Andrew Madin, Sawbridgeworth, GB;

Mark Peter Ridgill, Watton-At-Stone, GB;

Assignee:

Merck Sharp & Dohme Ltd., Hoddesdon, GB;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/433 (2006.01); A61P 25/28 (2006.01); C07D 285/14 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease


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