The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2006
Filed:
Jan. 23, 2003
Hayley Binch, Harwell, GB;
Guy Brenchley, Grove Wantage, GB;
Julian M. C. Golec, Swindon, GB;
Ronald Knegtel, Abingdon, GB;
Michael Mortimore, Burford, GB;
Sanjay Patel, Abingdon, GB;
Alistair Rutherford, Abingdon, GB;
Hayley Binch, Harwell, GB;
Guy Brenchley, Grove Wantage, GB;
Julian M. C. Golec, Swindon, GB;
Ronald Knegtel, Abingdon, GB;
Michael Mortimore, Burford, GB;
Sanjay Patel, Abingdon, GB;
Alistair Rutherford, Abingdon, GB;
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative thereof, wherein R, R, V, V, and Vare as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of AKT, PKA, PDK1, p70S6K, or ROCK kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment of various disorders.