The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2006
Filed:
Mar. 27, 1998
Collin J. Weber, Atlanta, GA (US);
Mary K. Hagler, Loganville, GA (US);
Peter S. Linsley, Seattle, WA (US);
Judith A. Kapp, Atlanta, GA (US);
Susan A. Safley, Decatur, GA (US);
Collin J. Weber, Atlanta, GA (US);
Mary K. Hagler, Loganville, GA (US);
Peter S. Linsley, Seattle, WA (US);
Judith A. Kapp, Atlanta, GA (US);
Susan A. Safley, Decatur, GA (US);
Emory University, Atlanta, GA (US);
Bristol Myers-Squibb Company, New York, NY (US);
Abstract
This invention provides a method of inhibiting viable cells transplanted into a subject from being destroyed by the subject's immune system which comprises: a) containing the viable cells, or tissue comprising the viable cells, prior to transplantation within a device comprising a semipermeable membrane; and b) treating the subject with a substance which inhibits an immune-system costimulation event in an amount effective to inhibit the subject's immune system from responding to said contained cells or tissue. In one embodiment, the substance which inhibits an immune-system costimulation event is CTLA4. Also provided by this invention is a method of treating diabetes in a subject which comprises: a) containing viable insulin-producing cells, or tissue comprising such cells, within a device comprising a semipermeable membrane; b) transplanting an effective amount of such contained viable insulin-producing cells into the subject; and c) treating the subject with an effective amount of a substance which inhibits an immune-system costimulation event.