The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2006
Filed:
Apr. 07, 1999
Applicant:
Guido Grandi, Segrate, IT;
Inventor:
Guido Grandi, Segrate, IT;
Assignee:
Chiron SRL, Siena, IT;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07G 7/00 (2006.01); A61K 39/12 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention relates to a process for enriching the presence ofNAP in a mixture of proteins. The process involves salting-out other proteins. NAP has been found to remain soluble at ammonium sulphate concentrations of 80% and above. The process may involve the additional step of metal chelate chromatography. The combination of salting-out and metal chelate chromatography results in very pure NAP. The NAP may have the same sequence as NAP naturally occurring inand is free from sequences typically associated with recombinant protein production. The processes and NAP of the invention can be used in diagnostic and therapeutic products and processes.