The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2006
Filed:
Oct. 26, 2001
Steven E. Ealick, Ithaca, NY (US);
William B. Parker, Birmingham, AL (US);
John A. Secrist, Iii, Birmingham, AL (US);
Eric J. Sorscher, Birmingham, AL (US);
Steven E. Ealick, Ithaca, NY (US);
William B. Parker, Birmingham, AL (US);
John A. Secrist, III, Birmingham, AL (US);
Eric J. Sorscher, Birmingham, AL (US);
Cornell Research Foundation, Inc., Ithaca, NY (US);
Southern Research Institute, Birmingham, AL (US);
The UAB Research Foundation, Birmingham, AL (US);
Abstract
The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells. The present invention provides nucleotide sequences encoding mutantderived purine nucleoside phosphorylase proteins which can be used in conjunction with an appropriate substrate to produce toxins which impair abnormal cell growth. The invention provides for delivery of the toxin by generation within target cells or by administration and delivery to the cells from without.