The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2006
Filed:
Mar. 20, 2001
Pamela M. Carroll, Princeton, NJ (US);
Jian Chen, Princeton, NJ (US);
Chandra S. Ramanathan, Wallingford, CT (US);
Hong Xiao, Princeton Junction, NJ (US);
Michael A. Bowen, Lawrenceville, NJ (US);
Pamela M. Carroll, Princeton, NJ (US);
Jian Chen, Princeton, NJ (US);
Chandra S. Ramanathan, Wallingford, CT (US);
Hong Xiao, Princeton Junction, NJ (US);
Michael A. Bowen, Lawrenceville, NJ (US);
Bristol-Myers Squibb, Princeton, NJ (US);
Abstract
The present invention provides novel polynucleotides encodingDmTNF polypeptides, fragments and homologs thereof. The present invention also is directed to novel polynucleotides encoding two Drosophila DmTNF variants, DmTNFv1 and DmTNFv2 polypeptides, fragments and homologs thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, in addition to methods of genetically modifying Drosophila or cultured cells to express or mis-express DmTNF, DmTNFv1, or DmTNFv2. The invention also relates to the use of such modified insects or cells to characterize DmTNF activity, identify TNF-like genes and/or genes implicated in modulating TNF, characterize TNF signaling pathways, and/or to identify modulators of DmTNF activity.