The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2006
Filed:
Jan. 26, 2005
Joo Young Chung, Sungnam-si, KR;
Sang Kyu Park, Seoul, KR;
Sang Myoung Ju, Sungnam-si, KR;
Hyea Kyung Ahn, Sungnam-si, KR;
Seung Wook Lim, Sungnam-si, KR;
Woo Ik Chang, Koonpo-si, KR;
Seung Kook Park, Sungnam-si, KR;
Yeo Wook Koh, Sungnam-si, KR;
Ji Soo Park, Seoul, KR;
Joo Young Chung, Sungnam-si, KR;
Sang Kyu Park, Seoul, KR;
Sang Myoung Ju, Sungnam-si, KR;
Hyea Kyung Ahn, Sungnam-si, KR;
Seung Wook Lim, Sungnam-si, KR;
Woo Ik Chang, Koonpo-si, KR;
Seung Kook Park, Sungnam-si, KR;
Yeo Wook Koh, Sungnam-si, KR;
Ji Soo Park, Seoul, KR;
Daewoong Pharmaceutical Co., Ltd., Seoul, KR;
Abstract
The present invention relates to novel human thrombopoietin (hTPO) derivatives, and to process of preparation thereof. Particularly, sugar chains are introduced into native hTPO by substituting amino acids such as asparagine for amino acids at specific positions in native hTPO, preparing novel hTPO derivatives with high activities enhancing the platelet production in vivo. Therefore, the novel hTPO derivatives of this invention may be useful for the treatment of thrombocytopenia associated with anticancer therapy or the transplantation of bone marrow.