The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2006
Filed:
Aug. 28, 2001
Gerald R. Kovacs, Rockville, MD (US);
Nikos Vasilakis, Galveston, TX (US);
Jacek Kowalski, Mahwah, NJ (US);
Seema Gangolli, Park Ridge, NJ (US);
Timothy Zamb, Nyack, NY (US);
Gerald R. Kovacs, Rockville, MD (US);
Nikos Vasilakis, Galveston, TX (US);
Jacek Kowalski, Mahwah, NJ (US);
Seema Gangolli, Park Ridge, NJ (US);
Timothy Zamb, Nyack, NY (US);
Wyeth Holdings Corporation, Madison, NJ (US);
Abstract
The invention generally relates to recombinant polynucleotides, positive-strand RNA virus (psRNAV) recombinant expression vectors, and packaging systems. The packaging systems are based on the expression of helper functions by coinfecting recombinant poxvirus vectors comprising recombinant polynucleotides. Methods for obtaining psRNAV replicon particles using these packaging systems are disclosed. Immunogenic compositions and pharmaceutical formulations are provided that comprise replicon particles of the invention. Methods for generating an immune response or producing a pharmaceutical effect are also provided.