The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2006
Filed:
Jan. 26, 2001
Beatriz M. Carreno, Acton, MA (US);
Clive Wood, Boston, MA (US);
Katherine Turner, Acton, MA (US);
Mary Collins, Natick, MA (US);
Gary S. Gray, Brookline, MA (US);
Donna Morris, Salem, NH (US);
Denise O'hara, Reading, MA (US);
Paul R. Hinton, Fremont, CA (US);
Naoya Tsurushita, Palo Alto, CA (US);
Beatriz M. Carreno, Acton, MA (US);
Clive Wood, Boston, MA (US);
Katherine Turner, Acton, MA (US);
Mary Collins, Natick, MA (US);
Gary S. Gray, Brookline, MA (US);
Donna Morris, Salem, NH (US);
Denise O'Hara, Reading, MA (US);
Paul R. Hinton, Fremont, CA (US);
Naoya Tsurushita, Palo Alto, CA (US);
Genetics Institue, LLC, Cambridge, MA (US);
Abstract
The invention provides an antibody-toxic moiety conjugates comprising an antibody that specifically recognizes a molecule expressed on the surface of a T cell which is expressed only on T cells and is only expressed transiently on T cells upon T cell activation. Preferably, the T cell molecule is CTLA4. The invention further provides anti-CTLA4 antibodies and humanized forms thereof.