The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2006
Filed:
Feb. 19, 2003
Tae-lim Choi, Pasadena, CA (US);
Choon Woo Lee, Pasadena, CA (US);
Hyunjin M. Kim, San Ramon, CA (US);
Robert H. Grubbs, South Pasadena, CA (US);
Tae-Lim Choi, Pasadena, CA (US);
Choon Woo Lee, Pasadena, CA (US);
Hyunjin M. Kim, San Ramon, CA (US);
Robert H. Grubbs, South Pasadena, CA (US);
California Institute of Technology, Pasadena, CA (US);
Abstract
This invention relates generally to synthetic procedures that include the step of ring-opening metathesis of cyclic olefins and reaction with an acyclic diene co-reactant to produce olefin macrocycles by ring expansion, or alternatively. The ring expansion of the cyclic olefin is provided by three types of sequential olefin metathesis (ring-opening, cross, and ring-closing olefin metathesis). More particularly, the invention pertains to synthesis of olefin macrocycles via olefin metathesis reactions using a Group 8 transition metal complex as the metathesis catalyst. Macrocycles provided herein have a variety of uses in the pharmaceutical, biomedical, organic synthesis and chemical industries, such as the production of crown ethers that are useful as metal complexing species.