The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2006
Filed:
Feb. 01, 2002
Satoru Oi, Nara, JP;
Koji Ikedou, Himeji, JP;
Koji Takeuchi, Chapel Hill, NC (US);
Masaki Ogino, Nishinomiya, JP;
Yoshihiro Banno, Suita, JP;
Hiroyuki Tawada, Takatsuki, JP;
Taihei Yamane, Takarazuka, JP;
Satoru Oi, Nara, JP;
Koji Ikedou, Himeji, JP;
Koji Takeuchi, Chapel Hill, NC (US);
Masaki Ogino, Nishinomiya, JP;
Yoshihiro Banno, Suita, JP;
Hiroyuki Tawada, Takatsuki, JP;
Taihei Yamane, Takarazuka, JP;
Takeda Pharmaceutical Company Limited, Osaka, JP;
Abstract
The present invention provides a compound of the formula: wherein ring A is an optionally substituted 5 to 10-membered aromatic ring; Rand Rare the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bond and the like; and L is a divalent hydrocarbon group, and a salt thereof, except 3-(aminomethyl)-2,6,7-trimethyl-4-phenyl-1(2H)-isoquinolinone, 3-(aminomethyl)-2-methyl-4-phenyl-1(2H)-isoquinolinone, 3-(aminomethyl)-6-chloro-2-methyl-4-phenyl-1(2H)-isoquinolinone and 3-(aminomethyl)-2-isopropyl-4-phenyl-1(2H)-isoquinolinone. The compound shows a superior peptidase-inhibitory activity and is useful as an agent for the prophylaxis or treatment of diabetes and the like.