The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2006
Filed:
Jul. 19, 2002
Ridgway Scott, Chicago, IL (US);
Stephen J. Wright, Madison, WI (US);
Stuart A. Kurtz, Homewood, IL (US);
Terry Clark, Chicago, IL (US);
Chris (Hristem) Dyanov, Chicago, IL (US);
Richard Quigg, Western Springs, IL (US);
Ridgway Scott, Chicago, IL (US);
Stephen J. Wright, Madison, WI (US);
Stuart A. Kurtz, Homewood, IL (US);
Terry Clark, Chicago, IL (US);
Chris (Hristem) Dyanov, Chicago, IL (US);
Richard Quigg, Western Springs, IL (US);
University of Chicago, Chicago, IL (US);
Abstract
A method for determining a matrix of expression levels corresponding to a set of biological targets (e.g., genes or gene fragments) and a set of biological samples, including obtaining a matrix of signal values corresponding to the set of biological targets; computing a vector of expression levels for a sample in the set of biological samples using the matrix of signal values; storing the vector of computed expression levels in a storage matrix; repeating the computing and storing steps for each sample in the set of biological samples; and outputting the storage matrix as the matrix of expression levels. The method, based on a linear programming formulation of the problem, works for both 'promiscuous' probe array data, in which there may be multiple targets indicated by a single probe, and the 'polygamous' case, in which there are multiple probes for a single target. The preferred method can also process data obtained from multiple SAGE analyses using multiple markers. A second embodiment of the method determines optimal expression levels when the available probe data is noisy or uncertain.