The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2006
Filed:
Aug. 02, 2004
Frank S. Gibson, Pennington, NJ (US);
Joydeep Kant, Cherry Hill, NJ (US);
Rajendra P. Deshpande, Hillsborough, NJ (US);
Karen L. Tenhuisen, Randolph, NJ (US);
Jing Liang, Princeton, NJ (US);
Jun LI, Langhorne, PA (US);
Susan D. Boettger, Fayetteville, NY (US);
Edward J. Gublo, Liverpool, NY (US);
Ulhas P. Dhokte, Jamesville, NY (US);
Frank S. Gibson, Pennington, NJ (US);
Joydeep Kant, Cherry Hill, NJ (US);
Rajendra P. Deshpande, Hillsborough, NJ (US);
Karen L. TenHuisen, Randolph, NJ (US);
Jing Liang, Princeton, NJ (US);
Jun Li, Langhorne, PA (US);
Susan D. Boettger, Fayetteville, NY (US);
Edward J. Gublo, Liverpool, NY (US);
Ulhas P. Dhokte, Jamesville, NY (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
A process is provided for preparing 4-alkyl- or 4-aryl-oxycarbonyl paclitaxel analogs which includes the steps of converting paclitaxel into a C-7 acylprotected paclitaxel employing an electrophilic protecting group, such as benzoyloxycarbonyl, and converting the C-7 protected analog into the 4-alkyloxycarbonyl or 4-aryloxycarbonyl paclitaxel analog. Novel intermediates produced in the process are also provided.