The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2006
Filed:
May. 03, 2005
Mark C. Noe, Mystic, CT (US);
Michael A. Letavic, Mystic, CT (US);
Louis S. Chupak, Old Saybrook, CT (US);
Kim F. Mcclure, Mystic, CT (US);
Mark C. Noe, Mystic, CT (US);
Michael A. Letavic, Mystic, CT (US);
Louis S. Chupak, Old Saybrook, CT (US);
Kim F. McClure, Mystic, CT (US);
Pfizer Inc, New York, NY (US);
Pfizer Products Inc., Groton, CT (US);
Abstract
This invention relates to a method of treatment for osteoarthritis involving inhibitors of aggrecanase that demonstrate ICs of less than 20 nM and demonstrate differential potency against matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs or reprolysins). This invention also relates to compounds, methods of treatment and composition of Formula I:or a therapeutically acceptable salt thereof, wherein