The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2006
Filed:
Dec. 27, 2002
John J. Talley, Brentwood, MO (US);
Stephen R. Bertenshaw, Brentwood, MO (US);
Paul W. Collins, Deerfield, IL (US);
Thomas D. Penning, Elmhurst, IL (US);
David B. Reitz, Chesterfield, MO (US);
Roland S. Rogers, Richmond Heights, MO (US);
John J. Talley, Brentwood, MO (US);
Stephen R. Bertenshaw, Brentwood, MO (US);
Paul W. Collins, Deerfield, IL (US);
Thomas D. Penning, Elmhurst, IL (US);
David B. Reitz, Chesterfield, MO (US);
Roland S. Rogers, Richmond Heights, MO (US);
G.D. Searle & Co., Chicago, IL (US);
Abstract
A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I:wherein Y is selected from O, S and NR; wherein Ris selected from hydrido and lower alkyl; wherein X is one or two substituent selected from hydrido, halo, lower alkoxycarbonyl and carboxyl; wherein Rand Rare independently aryl or heteroaryl; and wherein Rand Rare optionally substituted at a substitutable position with one or more radicals selected from sulfamyl, alkylsulfonyl, halo, lower alkoxy and lower alkyl; or a pharmaceutically-acceptable salt thereof.