The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2006
Filed:
Sep. 25, 2002
Marcello Allegretti, L'Aquila, IT;
Riccardo Bertini, L'Aquila, IT;
Cinzia Bizzarri, L'Aquila, IT;
Maria Candida Cesta, L'Aquila, IT;
Marcello Allegretti, L'Aquila, IT;
Riccardo Bertini, L'Aquila, IT;
Cinzia Bizzarri, L'Aquila, IT;
Maria Candida Cesta, L'Aquila, IT;
Dompé S.p.A., L'Aquila, IT;
Abstract
(R)-Enantiomers of quaternary ammonium salts of general formula (I) are described:where R, R, R, R, X and Z are as defined in the description. The process for their preparation and pharmaceutical preparations thereof are also described. The quaternary salts of the invention are useful in the inhibition of chemotaxis of neutrophils and monocytes induced by the fraction C5a of the complement and are used in the treatment of psoriasis, pemphigus and pemphigoid, rheumatoid arthritis, intestinal chronic inflammatory pathologies including ulcerative colitis, acute respiratory distress syndrome, idiopathic fibrosis, cystic fibrosis, chronic obstructive pulmonary disease and glomerulonephritis. The compounds of the invention are advantageously used in the prevention and the treatment of injury caused by ischemia and reperfusion.