The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2006
Filed:
Sep. 09, 2003
Akihiro Yamamoto, Tokushima, JP;
Norihiro Fukuyama, Tokushima, JP;
Yoshihiko Okaichi, Kitajima, JP;
Yasuhiro Yamada, Tokushima, JP;
Hisashi Miyamoto, Matsushige, JP;
Michiaki Tominaga, Kamiita, JP;
Akihiro Yamamoto, Tokushima, JP;
Norihiro Fukuyama, Tokushima, JP;
Yoshihiko Okaichi, Kitajima, JP;
Yasuhiro Yamada, Tokushima, JP;
Hisashi Miyamoto, Matsushige, JP;
Michiaki Tominaga, Kamiita, JP;
Otsuka Pharmaceutical Co., Ltd., Tokyo, JP;
Abstract
The present invention provides a process for producing cilostazol [I] in a high yield and a high purity, by reacting a carbostyril derivative [II] with a tetrazole derivative [III] in the presence of an inorganic basic compound in a solvent of water, wherein water is used in an amount of 3 to 7-fold weight to that of the carbostyril derivative [II] and the inorganic basic compound is used in an amount of 1 to 6 mol per mol of the carbostyril derivative [II]. The process of the present invention is the improved and environment-friendly process for producing cilostazol being useful for pharmaceuticals