The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2006
Filed:
Jun. 11, 2001
Jennifer Ann Chaplin, San Diego, CA (US);
Neil Stockenstrom Gardiner, Pretoria, ZA;
Robin Kumar Mitra, Benoni, ZA;
Christopher John Parkinson, Modderfontein, ZA;
Madrie Portwig, Greenside, ZA;
Butana Andrew Mboniswa, Edenvale, ZA;
Melanie Daryl Evans-dickson, Livingstone, ZM;
Dean Brady, Midrand, ZA;
Stephanus Francois Marais, Garsfontein, ZA;
Shavani Reddy, Edenvale, ZA;
Jennifer Ann Chaplin, San Diego, CA (US);
Neil Stockenstrom Gardiner, Pretoria, ZA;
Robin Kumar Mitra, Benoni, ZA;
Christopher John Parkinson, Modderfontein, ZA;
Madrie Portwig, Greenside, ZA;
Butana Andrew Mboniswa, Edenvale, ZA;
Melanie Daryl Evans-Dickson, Livingstone, ZM;
Dean Brady, Midrand, ZA;
Stephanus Francois Marais, Garsfontein, ZA;
Shavani Reddy, Edenvale, ZA;
CSIR, Pretoria, ZA;
Abstract
A process of separating a single desired stereoisomer from a racemic mixture of eight stereoisomers of a compound of formula (III), wherein Rrepresents an isopropanol group, an isopropyl group or an isopropylene group, includes the steps of: contacting the racemic mixture in a suitable organic solvent with an esterifying agent and a stereospecific enzyme which stereoselectively esterifies the —OH group of the desired stereoisomer, for a time sufficient to convert a desired percentage of the desired stereoisomer to a compound of formula (IV), wherein Ris as defined above and Ris an alkyl or an aryl group, to give a first reaction product including the compound of formula (IV), the organic solvent, the unconverted stereoisomers of the compound of formula (III), excess esterifying agent and by-products of the reaction; and separating the compound of formula (IV) from the first reaction product. The process is of particular application for the production of (−)-menthol