The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2006
Filed:
Mar. 06, 2001
Scott Hultgren, Ballwin, MO (US);
Meta Kuehn, Berkeley, CA (US);
Zheng Xu, Blue Bell, PA (US);
Derek Ogg, Uppsala, SE;
Mark Harris, Uppsala, SE;
Matti Lepisto, Lund, SE;
Charles Hal Jones, Saint Louis, MO (US);
Jan Kihlberg, Dalby, SE;
Scott Hultgren, Ballwin, MO (US);
Meta Kuehn, Berkeley, CA (US);
Zheng Xu, Blue Bell, PA (US);
Derek Ogg, Uppsala, SE;
Mark Harris, Uppsala, SE;
Matti Lepisto, Lund, SE;
Charles Hal Jones, Saint Louis, MO (US);
Jan Kihlberg, Dalby, SE;
Washington University, St. Louis, MO (US);
SIGA Pharmaceuticals, Inc., New York, NY (US);
Abstract
Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.