The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2006
Filed:
Nov. 04, 2003
Robert M. Burk, Laguna Beach, CA (US);
Mark Holoboski, Laguna Niguel, CA (US);
Mari F. Posner, Laguna Niguel, CA (US);
Robert M. Burk, Laguna Beach, CA (US);
Mark Holoboski, Laguna Niguel, CA (US);
Mari F. Posner, Laguna Niguel, CA (US);
Allergan, Inc., Irvine, CA (US);
Abstract
The invention relates to the use of derivatives of E-type prostaglandins as EPagonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the invention are represented by the following formula I:wherein the hatched segment represents an α bonds, the solid triangle represents a β bond, the wavy segments represent α or β bond, dashed lines represent a double bond or a single bond, X is selected from the group consisting of hydrogen and halogen radicals, Ris heteroaryl or a substituted heteroaryl radical, Rand Rare independently selected from the group consisting of hydrogen or a lower alkyl radical having up to six carbon atoms, or a lower acyl radical having up to six carbon atoms, R is selected from the group consisting of COR, CONR, CHOR, CONRSOR, P(O)(OR) andwherein Ris selected from the group consisting of H, phenyl and lower alkyl having from one to six carbon atoms and n is 0 or an integer of from 1 to 4.