The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2006
Filed:
Dec. 19, 2002
John W. Phillips, New Providence, NJ (US);
John W. Phillips, New Providence, NJ (US);
Rosetta Inpharmatics LLC, Seattle, WA (US);
Abstract
The present invention relates to methods of using nucleotide sequences from the promoter region of at least one of sevengenes whose expression is an indicator of the inhibition or modulation of the glucan synthase pathway inThis invention envisions using at least one target polynucleotide sequence, each target polynucleotide sequence being operably linked to the promoter region of one of the seven glucan synthase pathway reporter genes, to screen chemical libraries and natural products for compounds which can be used as antifungal agents for use against a variety of fungal pathogens. This invention also envisions using the methods of the invention to assay the efficacy of and/or specificity of antifungal agents, and/or to monitor the activity of the glucan synthase pathway.