The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2006
Filed:
Dec. 21, 2001
James M. Binley, Brooklyn, NY (US);
Norbert Schuelke, New City, NY (US);
William C. Olson, Ossining, NY (US);
Paul J. Maddon, Scarsdale, NY (US);
John P. Moore, New York, NY (US);
James M. Binley, Brooklyn, NY (US);
Norbert Schuelke, New City, NY (US);
William C. Olson, Ossining, NY (US);
Paul J. Maddon, Scarsdale, NY (US);
John P. Moore, New York, NY (US);
Progenics Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
This invention provides an isolated nucleic acid which comprises a nucleotide segment having a sequence encoding a viral envelope protein comprising a viral surface protein and a corresponding viral transmembrane protein wherein the viral envelope protein contains one or more mutations in amino acid sequence that enhance the stability of the complex formed between the viral surface protein and transmembrane protein. This invention also provides a viral envelope protein comprising a viral surface protein and a corresponding viral transmembrane protein wherein the viral envelope protein contains one or more mutations in amino acid sequence that enhance the stability of the complex formed between the viral surface protein and transmembrane protein. This invention further provides methods of treating HIV-1 infection.