The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2006
Filed:
Nov. 19, 2002
Robert Koll, Kirchheim, DE;
Jutta Müller-derlich, Germering, DE;
Stephan Felix, Falkensee, DE;
Petra Reinke, Berlin, DE;
Stefan Brehme, Berlin, DE;
Gert Baumann, Berlin, DE;
Reiner Spaethe, Stamberg, DE;
Robert Koll, Kirchheim, DE;
Jutta Müller-Derlich, Germering, DE;
Stephan Felix, Falkensee, DE;
Petra Reinke, Berlin, DE;
Stefan Brehme, Berlin, DE;
Gert Baumann, Berlin, DE;
Reiner Spaethe, Stamberg, DE;
Edwards Lifesciences Corporation, Irvine, CA (US);
Abstract
Immunoapheresis treatment for cardiomyopathy comprises passing the patient's plasma over a column having coupled thereto a specific ligand for human immunoglobulin, thereby removing a significant portion of the immunoglobulin from the patient's plasma, and then reinfusing the plasma to the patient. The invention is the use of a specific ligand for human immunoglobulin in the manufacture of a column having the ligand coupled thereto, the column being useful for immunoapheresis treatment of a patient with cardiomyopathy. The specific ligand binds, and thereby removes, human autoantibodies which are harmful to cardiac tissue such as antibodies against β-adrenergic receptors, ADP-ATP carriers, α and β myosin heavy chains, and adenine nucleotide translocators. Immunoapheresis treatment using the column results in improvement of hemodynamic parameters such as mean arterial pressure, mean pulmonary pressure, pumonary capillary wedge pressure, right atrial pressure, cardiac output, cariac index, stroke volume index, and systemic vascular resistance.