The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2006
Filed:
Dec. 17, 2003
Yang-dar Yuan, Irvine, CA (US);
Richard L. Beard, Newport Beach, CA (US);
Roshantha A. Chandraratna, Laguna Hills, CA (US);
Yang-Dar Yuan, Irvine, CA (US);
Richard L. Beard, Newport Beach, CA (US);
Roshantha A. Chandraratna, Laguna Hills, CA (US);
Allergan, Inc., Irvine, CA (US);
Abstract
Diabetic mammals are treated with compounds that are significantly more efficacious as agonists of RXRretinoid receptors than as agonists of RXRor RXRretinoid receptors. The treatment reduces serum glucose and triglyceride levels of the mammals without the undesirable side effects of reducing serum thyroxine levels and a transient increase in serum triglyceride levels Compounds suitable for use in the methods of treatments of the present invention are selected by testing and identifying compounds of selective or specific efficacy as agonists of RXRretinoid receptors in preference over RXRand/or RXRretinoid receptors. Novel compounds used in the methods of the invention have Formula 1 where the variables are defined as disclosed in the specification.