The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 28, 2006

Filed:

Sep. 11, 2000
Applicants:

Henrik Sune Andersen, Lyngby, DK;

Thomas Kruse Hansen, Herlev, DK;

Jesper Lau, Farum, DK;

Niels Peter Hundahl Møller, København Ø, DK;

Ole Hvilsted Olsen, Brønshøj, DK;

Frank Urban Axe, Escondido, CA (US);

Yu GE, San Diego, CA (US);

Daniel Dale Holsworth, San Diego, CA (US);

Todd Kevin Jones, Solana Beach, CA (US);

Luke Milburn Judge, Seattle, WA (US);

Wiliam Charles Ripka, San Diego, CA (US);

Barry Zvi Shapira, La Jolla, CA (US);

Roy Teruyuki Uyeda, San Diego, CA (US);

Inventors:

Henrik Sune Andersen, Lyngby, DK;

Thomas Kruse Hansen, Herlev, DK;

Jesper Lau, Farum, DK;

Niels Peter Hundahl Møller, København Ø, DK;

Ole Hvilsted Olsen, Brønshøj, DK;

Frank Urban Axe, Escondido, CA (US);

Yu Ge, San Diego, CA (US);

Daniel Dale Holsworth, San Diego, CA (US);

Todd Kevin Jones, Solana Beach, CA (US);

Luke Milburn Judge, Seattle, WA (US);

Wiliam Charles Ripka, San Diego, CA (US);

Barry Zvi Shapira, La Jolla, CA (US);

Roy Teruyuki Uyeda, San Diego, CA (US);

Assignee:

Novo Nordisk A/S, Bagsvaerd, DK;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/381 (2006.01); C07D 409/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed are novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like,wherein n, m, X, Y, R, R, R, R, Rand Rare defined more fully in the description. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.


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