The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2006
Filed:
Jun. 09, 2003
Applicants:
Richard Drake, Little Rock, AR (US);
Trenton Hinds, Portsmouth Commonwealth, DM;
Cesar Compadre, Little Rock, AR (US);
Barry Hurlburt, Little Rock, AR (US);
Tammy Rechtin, Birmingham, AL (US);
Inventors:
Richard Drake, Little Rock, AR (US);
Trenton Hinds, Portsmouth Commonwealth, DM;
Cesar Compadre, Little Rock, AR (US);
Barry Hurlburt, Little Rock, AR (US);
Tammy Rechtin, Birmingham, AL (US);
Assignee:
The Board of Trustees of the University of Arkansas, Little Rock, AR (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided is a method of killing target cells using such mutants combined with a prodrug.