The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2006
Filed:
Feb. 12, 2002
Hak-kim Chan, North Sydney, AU;
Igor Gonda, San Francisco, CA (US);
Steven J. Shire, Belmont, CA (US);
Suzanne Sin-mui Lo Weck, Mountain View, CA (US);
Hak-Kim Chan, North Sydney, AU;
Igor Gonda, San Francisco, CA (US);
Steven J. Shire, Belmont, CA (US);
Suzanne Sin-Mui Lo Weck, Mountain View, CA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
The present invention relates to the use of calcium ion and/or sugars to minimize thermal aggregation of DNase and to the use of calcium ion to stabilize liquid solutions of DNase, the solutions having a pH of less than neutral. DNase is the active pharmaceutical principle and the solutions may contain other pharmaceutically acceptable excipients making them suitable for pharmaceutical administration. In the first instance, calcium ion/sugar minimizes the effects of thermal aggregation in the solution. In the second aspect, calcium ion stabilizes the lower pH solutions from protein precipitation.