The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2006
Filed:
Nov. 05, 2001
Robert H. Oakley, Durham, NC (US);
Lawrence S. Barak, Durham, NC (US);
Stephane A. Laporte, Outremont, CA;
Marc G. Caron, Hillsborough, NC (US);
Robert H. Oakley, Durham, NC (US);
Lawrence S. Barak, Durham, NC (US);
Stephane A. Laporte, Outremont, CA;
Marc G. Caron, Hillsborough, NC (US);
Duke University, Durham, NC (US);
Abstract
The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have carboxyl terminal tails comprising one or more sites of phosphorylation, preferably one or more clusters of phosphorylation sites. The modified GPCRs of the present invention may comprise a retained portion of a carboxyl-terminus region from a first GPCR fused to a polypeptide, wherein the polypeptide comprises the one or more clusters of phosphorylation. The present invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRs.