The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 21, 2006

Filed:

Apr. 15, 1999
Applicants:

Leo J. Romancyzk, Jr., Hackettstown, NJ (US);

Amit Basak, Baltimore, MD (US);

Craig A. Townsend, Baltimore, MD (US);

Inventors:

Leo J. Romancyzk, Jr., Hackettstown, NJ (US);

Amit Basak, Baltimore, MD (US);

Craig A. Townsend, Baltimore, MD (US);

Assignee:

Mars Incorporated, Mclean, VA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 311/62 (2006.01); C07D 311/60 (2006.01); C07D 311/32 (2006.01); C07H 17/06 (2006.01); A61K 31/35 (2006.01);
U.S. Cl.
CPC ...
Abstract

Processes are disclosed for the production of linear and branched procyanidin oligomers having 'n' procyanidin monomeric units where n is 2 to 18. The processes include coupling protected, activated monomers with an unprotected monomer to produce a partially protected (4→8) dimer. The dimer is optionally blocked, coupled with an activated protected monomer to produce a partially protected, optionally blocked trimer, and deprotected. The steps can be repeated to produce higher oligomers. Processes are also provided for producing (8→8), (8→6), and (6→6) dimers and doubly branched oligomers. Crystalline 8-bromo-tetra-O-benzyl-(−)-epicatechin is produced under certain conditions.


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