The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 21, 2006
Filed:
Nov. 05, 2002
Sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms
Applicants:
Tamar Nidam, Yehud, IL;
Marioara Mendelovici, Rechovot, IL;
Eduard Schwartz, Rehovot, IL;
Shlomit Wizel, Petah Tiqva, IL;
Inventors:
Tamar Nidam, Yehud, IL;
Marioara Mendelovici, Rechovot, IL;
Eduard Schwartz, Rehovot, IL;
Shlomit Wizel, Petah Tiqva, IL;
Assignee:
Teva Pharmaceutical Industries Ltd., Petah Tiqva, IL;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 261/20 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to a novel sulfonation of an intermediate of zonisamide. The sulfonation processes using chlorosulfonic acid as well as acetic anhydride and sulfuric acid in an organic solvent are disclosed. Crystalline forms of benzisoxazole methane sulfonic acid (BOS—H) and its salts (BOS—Na, BOS—Ca, and BOS—Ba) and their novel preparation processes are disclosed.