The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 21, 2006
Filed:
May. 10, 2000
Nouri Neamati, Fullerton, CA (US);
Yves Pommier, Bethesda, MD (US);
Antonio Garofalo, Siena, IT;
Vito Nacci, Siena, IT;
Nouri Neamati, Fullerton, CA (US);
Yves Pommier, Bethesda, MD (US);
Antonio Garofalo, Siena, IT;
Vito Nacci, Siena, IT;
Abstract
The present invention discloses non-catechol compounds, such as thiazolothiazepines, and analogs and derivatives thereof, which are anti-integrase inhibitors. The compounds, which are useful as treatments for HIV disease, include compounds (I), (II), (III), or pharmaceutically acceptable salts thereof wherein A is thiazole, benzene, naphthalene, pyridine, pyrimidine, pyrazine, or quinoline; R is one or more of H, halogen, lower alkyl, lower alkoxy, NO, lower ester or carboxylic acid; X—Y is CH—S, S—CH, CH—O, CH—S(O). S(O)—CH, CH—CH, CH—CH—CH, or CH—CH—CH—CH; Ris H or hydroxy; Ris H, phenyl, or alkylamine; W is S or O; and Ris H, substituted or unsubstituted alkyl or amine; and Z is S, O, CH, CHCH, or C═O.