The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2006
Filed:
Sep. 23, 2002
Konrad Bleicher, Freiburg, DE;
Scott Borthwick, Galashiels, GB;
Hans Iding, Rheinfelden, DE;
Mark Rogers-evans, Binningen, CH;
Stefan Schmid, Basel, CH;
Han Min Tong, Antony, FR;
Beat Wirz, Reinach, CH;
Konrad Bleicher, Freiburg, DE;
Scott Borthwick, Galashiels, GB;
Hans Iding, Rheinfelden, DE;
Mark Rogers-Evans, Binningen, CH;
Stefan Schmid, Basel, CH;
Han Min Tong, Antony, FR;
Beat Wirz, Reinach, CH;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
The present invention relates to a new process for the preparation compounds of formula Iwherein R, R, Rand n are as described in the description which process comprises reacting compounds of formula IIwherein R, R, R, n and Rare as described in the description, with a protease in an aqueous system containing an organic co-solvent. The compound of formula I are useful for the preparation of 1,5-benzothiazepines which are useful as enzyme inhibitors, such as protease, interleukin-1β-converting enzyme, elastase or angiotensin converting enzyme, GPCR antagonists (cholecystokinin, angiotensin II receptor).