The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2006
Filed:
Apr. 25, 2002
Ale{hacek Over (S)} Halama, Pardubice, CZ;
Ludmila Hejtmánková, Prelouc, CZ;
Petr Lustig, Pardubice, CZ;
Jind{hacek Over (R)}ich Richter, Pardubice, CZ;
Lucie Sr{hacek Over (Sn)}ová, Chrudim, CZ;
Josef Jirman, Pardubice, CZ;
Ale{hacek over (s)} Halama, Pardubice, CZ;
Ludmila Hejtmánková, Prelouc, CZ;
Petr Lustig, Pardubice, CZ;
Jind{hacek over (r)}ich Richter, Pardubice, CZ;
Lucie Sr{hacek over (sn)}ová, Chrudim, CZ;
Josef Jirman, Pardubice, CZ;
Zentiva A.S., Praha 10, CZ;
Abstract
A method for obtaining antidiabetic of formula (I), wherein the method comprises condensing of a 4-derivatized phenol or phenolate of general formula (II), wherein R is an amino group-containing organic residue, selected from the group comprising a residue of the following formula —NHR, wherein Ris hydrogen or a protecting group, which is removed before further treatment, and a residue of general formula (A), wherein Rrepresents a carboxy group either in the free acid form or in the form of a salt or ester or another functional derivative or the nitrile group CN, and M represents a hydrogen or alkali metal atom, with a pyridine base of general formula (III, wherein Z is a leaving group other than a halogen, wherein, before or after carrying out the condensation, the following operations are carried out: (a) diazotizing the amino group present in organic residue R; (b) converting the diazotised residue R into a derivative of 2-halopropionate or 2-halopropionitrile of formula (B), wherein Ris as defined above and X is a halogen; (c) cyclizing the derivative of 2-halopropionate or 2-halopropionitrile with thiourea; (d) hydrolysing the resulting imine thus giving pioglitazone of formula (I)