The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2006
Filed:
Apr. 30, 2003
Sung-gyu Kim, Daejeon, KR;
Yoon Sung Jung, Gyeonggi-do, KR;
Jae Yang Kong, Daejeon, KR;
Woo Kyu Park, Chungcheongbuk-do, KR;
Sung-Gyu Kim, Daejeon, KR;
Yoon Sung Jung, Gyeonggi-do, KR;
Jae Yang Kong, Daejeon, KR;
Woo Kyu Park, Chungcheongbuk-do, KR;
Yungjin Pharmaceuticals Co., Ltd., Seoul, KR;
Korea Research Institute of Chemical Technology, Daejeon, KR;
Abstract
The present invention relates to new quinoline derivatives of formula (1) or their pharmaceutically acceptable salts with caspase-3 inhibitory activity and their preparation methods, wherein Ris H; halogen; Calkyl; Calkoxy; Calkoxyalkyl; or Ccycloalkyl; Ris formula (a); —CN; or formula (b); R is H; Caryl unsubstituted or substituted by halogen, Calkyl, Calkoxy or amino; 5–15 membered heterocyclic group unsubstituted or substituted by halogen, Calkyl, Calkoxy or amino; or —(CH)—CHRR. The present invention relates to a pharmaceutical composition for treating caspase-associated diseases by inhibiting the activity of caspase-3 which comprises the compound of formula (1) or its pharmaceutically acceptable salt.