The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2006
Filed:
Mar. 26, 1999
Michael Jaye, Glenside, PA (US);
Kim-anh Thi Doan, Spring City, PA (US);
John A. Krawiec, Gulph Mills, PA (US);
Kevin J. Lynch, Gurnee, IL (US);
Dilip V. Amin, Lansdale, PA (US);
Victoria J. South, Collegeville, PA (US);
Dawn Marchadier, Sickelerville, NJ (US);
Cyrille Maugeais, Philadelphia, PA (US);
Daniel J. Rader, Collegeville, PA (US);
Michael Jaye, Glenside, PA (US);
Kim-Anh Thi Doan, Spring City, PA (US);
John A. Krawiec, Gulph Mills, PA (US);
Kevin J. Lynch, Gurnee, IL (US);
Dilip V. Amin, Lansdale, PA (US);
Victoria J. South, Collegeville, PA (US);
Dawn Marchadier, Sickelerville, NJ (US);
Cyrille Maugeais, Philadelphia, PA (US);
Daniel J. Rader, Collegeville, PA (US);
Aventis Pharmaceuticals Inc., Bridgewater, NJ (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
The present invention relates to compositions for use in raising or lowering the level of LIPG polypeptide in a patient. Embodiments of the composition include compositions comprising: an anti-sense nucleic acid; a neutralizing antibody; an intracellular binding protein; an inhibitor which inhibits the enzymatic activity of LIPG polypeptide; an inhibitor which inhibits the expression of LIPG gene; a ribozyme; an LIPG polypeptide; an enhancer which increases the enzymatic activity of LIPG polypeptide; or an enhancer which increases the expression of LIPG gene. The invention relates also to methods for using the above compositions. In addition, the invention relates to a method for diagnosing a predisposition to lower cholesterol, a method for determining whether a test compound can inhibit the enzymatic reaction between LIPG polypeptide and HDL cholesterol, and methods for determining whether a test compound can enhance the enzymatic reaction between LIPG polypeptide and LDL or VLDL cholesterol.