Method and apparatus for desolvating ions for introduction into a faims analyzer region

Abstract

Disclosed are an apparatus and a method for separating ions produced at an electrospray ionization source, based upon the high field mobility properties of the ions. An apparatus according to the instant invention includes a high field asymmetric waveform ion mobility spectrometer (FAIMS) having an analyzer region defined by a space between an inner electrode () and an outer electrode (). In particular, the outer electrode includes an ion inlet () for introducing ions into a first portion of analyzer region and an ion outlet () for extracting ions from a second portion of the analyzer region. The FAIMS is characterized in that a gas-directing conduit () is provided through at least a portion of the inner electrode. In particular, the gas-directing conduit includes an opening at a first end thereof for supporting fluid communication between the gas-directing conduit and the first portion of the analyzer region. The gas-directing conduit is adapted at a second end thereof opposite the first end for supporting fluid communication between a gas source and the gas-directing conduit. The opening is orientated relative to the ion inlet such that gas provided through the gas-directing conduit flows partially outwardly from the analyzer region through the ion inlet, so as to desolvate the ions produced at an ionization source () as they are introduced into the analyzer region.