The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 28, 2006

Filed:

Aug. 18, 2004
Applicants:

Chin-ti Chen, Taipei, TW;

Hsiu-chih Yeh, Taipei, TW;

Inventors:

Chin-Ti Chen, Taipei, TW;

Hsiu-Chih Yeh, Taipei, TW;

Assignee:

Academia Sinica, Taipei, TW;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07B 47/00 (2006.01); A61B 5/055 (2006.01); A61B 10/00 (2006.01); C07F 5/10 (2006.01); A61K 31/555 (2006.01);
U.S. Cl.
CPC ...
Abstract

This invention relates to a method of preparing a compound of formula (I):The method includes reacting one or more compounds of formula (II):in the presence of a base and a halogenating agent. In formulas (I) and (II) above, each A, independently, is aryl or heteroaryl; each n, independently, is 0–3; and each R, independently, is C–Calkyl, C–Ccycloalkyl, C–Cheterocycloalkyl, aryl, heteroaryl, halo, cyano, nitro, OR, NRR, SiRRR, COOR, OC(O)R, C(O)NRR, N(R)—C(O)R, or SOR; wherein each of R, R, and R, independently, is H, C–Calkyl, C–Ccycloalkyl, C–Cheterocycloalkyl, aryl, or heteroaryl; thereby producing the compound of formula (I) in a one-pot reaction. This invention also relates to the compounds prepared by the method described above.


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