The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2006
Filed:
Nov. 29, 2000
Vanessa Hsei, San Jose, CA (US);
Iphigenia Koumenis, Palo Alto, CA (US);
Steven Leong, Berkeley, CA (US);
Leonard Presta, San Francisco, CA (US);
Zahra Shahrokh, San Francisco, CA (US);
Gerardo Zapata, Foster City, CA (US);
Vanessa Hsei, San Jose, CA (US);
Iphigenia Koumenis, Palo Alto, CA (US);
Steven Leong, Berkeley, CA (US);
Leonard Presta, San Francisco, CA (US);
Zahra Shahrokh, San Francisco, CA (US);
Gerardo Zapata, Foster City, CA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment.