The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2006
Filed:
Dec. 02, 2002
Yolande Lydia Lang, Vosselaar, BE;
Bart Petrus Anna Maria Jozef Medaer, Lille, BE;
Georges Joseph Cornelius Hoornaert, Kessel-Lo, BE;
Thierry Brossette, Montpellier, FR;
Frans Josef Cornelius Compernolle, Herent, BE;
Michel Joseph Maurice André Guillaume, Berg, BE;
Hua Mao, Leuven, BE;
Tomasz Kozlecki, Leuven, BE;
Yolande Lydia Lang, Vosselaar, BE;
Bart Petrus Anna Maria Jozef Medaer, Lille, BE;
Georges Joseph Cornelius Hoornaert, Kessel-Lo, BE;
Thierry Brossette, Montpellier, FR;
Frans Josef Cornelius Compernolle, Herent, BE;
Michel Joseph Maurice André Guillaume, Berg, BE;
Hua Mao, Leuven, BE;
Tomasz Kozlecki, Leuven, BE;
Janssen Pharmaceutica N.V., Beerse, BE;
Abstract
The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I)in stereochemically pure form from either of two enantiomerically pure precursors. The tetracyclic ringsystem having trans-fused five and seven membered rings is formed in an acid-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a medicine, in particular as CNS active medicines.